I am probably a very small segment of the population that uses the Dvorak keyboard for typing.  I switched many many years ago and haven’t looked back.  I recently was trying to see how difficult it would be to remap the cut/copy/paste keys.

Below is the script I used to remap with AutoIt –

AutoMapKey

 ; Remap ctrl copy, cut, paste.
 ; remaps the originals back to the standard english keyboard
 ^j::^c
 ^q::^x
 ^k::^v
 ToolTip You pressed %A_ThisHotkey%.
 return